https://petermcculloughmd.substack.com/p/benefits-of-ozone-on-mortality-in?
Benefits of Ozone on Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis
Small Studies Found Benefit Yet Adjunctive Therapy Not Advanced to Large, Multicenter Trials
By Peter A. McCullough, MD, MPH
I attended an integrative medicine meeting recently and one of the speakers said that ozone was one of the most important tools in his practice. While this is a very broad topic with > 4000 papers listed in the National Library of Medicine with the MESH term “ozone therapy,” Hu et al briefly summarized:
“Ozone is a molecule composed of three oxygen atoms and a component of the atmosphere in nature, which has a strong oxidizing action. Ozone has a high-energy, variable molecular structure under normal temperature and is quickly and spontaneously decomposed into O2 and a single oxygen atom (O). It has strong activity in oxidation and a strong bactericidal effect on bacteria and viruses.10,11 Ozone therapy inactivates bacteria by disrupting their cell envelope through oxidation of phospholipids and lipoproteins, inhibits fungi growth, damages the capsid of viruses, and upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.12 Oxygen-ozone therapy causes an increase in the rate of red blood cell glycolysis, causing the stimulation of 2,3-diphosphoglycerate, which leads to an increase in oxygen released to the tissues.13”
Innovative physicians, from many parts of the world trialed ozone in hospitalized patients some of whom had 4-6 weeks in the hospital with acute COVID-19. Shang et al performed a meta-analysis of very small studies…. (See link for article)
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https://pubmed.ncbi.nlm.nih.gov/36513208/
Benefits of ozone on mortality in patients with COVID-19: A systematic review and meta-analysis
- PMID: 36513208
- PMCID: PMC9737514
- DOI: 10.1016/j.ctim.2022.102907
Abstract
Background: The Coronavirus disease-2019 (COVID-19) pandemic continues, and the death toll continues to surge. Ozone therapy has long been used in the treatment of a variety of infectious diseases, probably through its antioxidant properties and the supply of oxygen to hypoxic tissues. This systematic review and meta-analysis aimed to determine the efficacy of ozone on mortality in patients with COVID-19.
Methods: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Prospective controlled trials on treatment of COVID-19 with ozone, compared with placebo or blank, were reviewed. Studies were pooled to risk ratios (RRs) and weighted mean differences (WMDs), with 95% confidence intervals (CIs).
Results: Eight trials (enrolling 371 participants) met the inclusion criteria. Ozone therapy showed significant effects on mortality (RR 0.38, 95% CI 0.17-0.85; P = 0.02), length of hospital stay (WMD -1.63 days, 95% CI -3.05 to -0.22 days; P = 0.02), and polymerase chain reaction (PCR) positivity (RR 0.07, 95% CI 0.01-0.34; P = 0.001).
Conclusions: Ozone therapy significantly reduced mortality, PCR positivity, and length of stay in hospitalized patients with COVID-19. Ozone therapy should be considered for COVID-19 patients.
https://pubmed.ncbi.nlm.nih.gov/33169118/
Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy
- PMID: 33169118
- PMCID: PMC7609231
- DOI: 10.1016/j.xinn.2020.100060
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