Madison Area Lyme Support Group

Updated: 9/19/23

This update includes a review of research published by the manufacturer of Lyme SOT in late 2022. Based on my review of this new science, I have retitled this article: Is SOT for Lyme & Tick-borne Infections a Scam?

Probability of Health Improvement

• My clinical experience: not enough experience to say
• MyLymeData: no research conducted
• RGCC Funded Research: biased study with inadequate data
• Placebo effect benefit of any prescription medicine: 30-40 percent

For more information about the best research-supported germ killing approaches to recover from Lyme disease see What Works? Navigating Prescription & Alternative Medicine Lyme Treatments.

Supportive Oligonucleotide Therapy Background

Supportive Oligonucleotide Therapy (SOT) is a new treatment for Lyme disease. SOT is also called Antisense Oligonucleotide Therapy (ASOT), which is the term used in medical research papers. SOT uses laboratory-derived nucleic acids (genetic code) that blocks production of disease-causing proteins or even gene expression. These pieces of genetic code are called oligonucleotides. You can think of oligonucleotides as a genetic message.

For example, in Duchenne muscular dystrophy (DMD), SOT provides oligonucleotides to direct the correct production of a protein called dystrophin. People with muscular dystrophy are born with DNA that provides the wrong genetic message for dystrophin. SOT correction to the DNA message leads to production of dystrophin. This prevents the muscle damage seen in DMD.

In Lyme disease, a currently available type of SOT produced by RGCC in Greece uses oligonucleotides to stop germ growth and replication. Unlike the SOT therapy for DMD, the Lyme SOT is not an FDA-approved drug. To be approved by the FDA, a therapy must have scientific evidence of safety and effectiveness.

As I explain below, SOT does not alter DNA. Instead, it provides a short-term change to how the DNA blueprint is expressed.  (See link for article)

For more:

• https://madisonarealymesupportgroup.com/2023/04/27/study-sot-potential-treatment-for-viruses-lyme-disease/
• https://madisonarealymesupportgroup.com/2022/09/23/overcome-bacterial-viral-infections-with-sot-and-rgcc-test/
• https://madisonarealymesupportgroup.com/2020/12/22/sot-treatment-for-lyme-disease/
• For one woman’s Lyme/SOT experience:  https://lymedisease.org.au/dees-lyme-journey-was-sot-the-answer-in-the-end/  (Please know she did years of antibiotics and even hyperthermia before SOT.  This is often the case with patients and must be factored into the equation when someone gives one thing all the credit.  Success is often the result of many modalities. The hardest thing for patients to accept is the fact testing is worthless and if you are chronically infected, successful treatment will require many, many modalities.)