Madison Area Lyme Support Group

Please see the letter below regarding Dr. Horowitz’s recent laboratory findings on the effects of dapsone and intracellular antibiotics as a possible treatment for this antibiotic resistant/tolerant superbug responsible for chronic Lyme disease.

———- Original Message ———-

From: CARL TUTTLE <runagain@comcast.net>
To: “tickbornedisease@hhs.gov” <tickbornedisease@hhs.gov>
Cc: (97 Undisclosed recipients)
Date: 10/01/2020 8:51 AM
Subject: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

To the Tick-Borne Disease Working Group,

When will our public health officials stop denying that we’re dealing with an antibiotic resistant/tolerant superbug?

Where is the GOVERNMENT DRIVEN MANHATTAN PROJECT to find a cure?  BMC Research Notes

Published: 29 September 2020

Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

Richard I. Horowitz, Krithika Murali, Gauri Gaur, Phyllis R. Freeman & Eva Sapi

https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-020-05298-6

Excerpt:

Several theories to explain persistent symptoms have been suggested, including immune evasion in privileged sites [14], antigenic variation [15], persistent antigenic stimulation [16], biofilm formation [17, 18] and B. burgdorferi persister cells, a highly resistant bacterial form which may protect the bacteria from antibacterial therapy. B. burgdorferi can exist in spirochetal, round body forms, intracellularly, as well as in newly discovered biofilm forms [4, 19,20,21,22,23,24,25,26,27,28,29]. Previous data suggested that standard and some newly discovered antibiotics for Lyme disease can be very effective in eliminating spirochetal, round body, intracellular and antibiotic tolerant persister cells [4, 20, 25,26,27] but have little effect on biofilm forms [24, 30]. Persisters are multi-drug tolerant cells present in significant numbers in biofilms [27, 29], and the importance of Borrelia biofilms has been highlighted in autopsy tissues from a well-documented Lyme disease patient [31]. Therefore, to successfully treat Lyme disease, there is an urgent need to find an agent or combination of antimicrobial agents which can efficiently eliminate resistant biofilm forms of B. burgdorferi.

Carl Tuttle

Lyme Endemic Hudson, NH

___________________

**Comment**

Unfortunately, mainstream medicine denies borrelia is pleomorphic & persistent, and calls it ‘quack’ science. This polarization has continued unabated since the 80’s when the Bayh Dole Act was passed authorizing federal agencies to grant exclusive licenses to inventions owned by the federal government.^[7]  Since that time, those entrusted with public health have vested financial interests in the form of patents.  At the same time, monies for research came more and more from the federal government – creating an unholy alliance between the government, research institutions, and manufacturing.  This is the corrupted root that has now given way to politicized science that is dominating the research world.

The denial and conflicts have been felt by thousands upon thousands of Lyme/MSIDS patients as well as doctors who defy the narrative.

I’m about 75% done with Polly Murray’s, “The Widening Circle,” which details her family’s experience with tick-borne illness as well as the early history of Lyme.

I must admit the information makes me even more frustrated over the lack of response to this debilitating illness.  It’s been over 40 years and yet the polarizing controversy continues and we have so little to show for something that is debilitating/killing people.

I plan to write a summary of the book when I’m through but it’s a whopper and almost familiar in that her litany of symptoms experienced by her ENTIRE family takes me back to my own bitter journey.  If you haven’t read her book, I highly recommend it.  But, prepare to be frustrated!