ejbps, 2019, Volume 6, Issue 8, 464-468.

Year: 2019


Barbaros ÇETİN*

Dokuz Eylül University, Faculty of Science, Department of Biology, Izmir, Turkey.

*Corresponding Author: Barbaros ÇETİN


Lyme borreliosis is well known multisystem disease and can produce a wide array of neurological abnormalities in humans. It can effect both the central and peripheral nervous system. Spinal muscular atrophy (SMA) a leading genetic cause of infant death, is a neurodegenerative disease characterised by the selective loss of particular groups of motor neurones in the anterior horn of the spinal cord with concomitant muscle weakness. Spinal muscular atrophy (SMA) is also a neuromuscular disease caused by abnormally low cellular levels of the ubiquitous protein SMN. Recent study finds connection between ALS and SMA. Respiratory failure due to bilateral diaphragm palsy as an early manifestation of ALS. Diaphragmatic paralysis and respiratory failure as a complication of Lyme disease. Lyme –associated diaphragm weakness from phrenic nerve palsy is rare. One of the rarest manifestations of phrenic nerve disorder is neuroborreliosis. I report two cases.

  1. When she was 2 months baby, she had diagnosed with SMA. After three years, her LTT-Borrelia test result is positive. CD57+/CD3-(NK cells) % 0.48, (20 mm 3 ), very low. C3 Compleman test result is low. Her mother’s (38 years old), LTT-Borrelia test result also positive. It is documented that transplacental transmission of the spirochete from mother to fetus is possible.
  2. 13 years old son. He had diagnosed Emery-Dreifuss muscular dystrophy (EDMD),when he was 6 years old. He had, LTT-Borrelia positive test result, after 5 years. His father lyme test result was positive, when he was 57 years old.

Eventually, these results reveal the need for consideration of Lyme borreliyosis in patients diagnosed with SMA for the first time.

People who are diagnosed with SMA, DMD, ALS and similar neurodegenerative diseases have a great benefit in performing Lyme tests.



I highly doubt that SMA is a “new” complication of Lyme disease – but rather is newly published information. Again, with all the under reporting going on, we haven’t a clue about prevalence in patients.

This article also highlights congenital transmission of Lyme disease – something the CDC doesn’t even recognize to date:

Which brings up the potential of sexual transmission as well:

It continues to battle me why authorities will not do the appropriate studies on much needed practical issues such as sensitive testing, appropriate treatment, and whether or not Lyme/MSIDS can be transmitted by numerous means:

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